Aminotadalafil

Inventory Status:
Available

Product Details

AvailabilityIn stock

SKUAMINOTADA

CategoryAnalytical Reagents

Brand4-Amino-Labs

SKU AMINOTADA Category Analytical Reagents Tags amino tadalafil, tadalafil Brand: 4-Amino-Labs

Price range: $48.00 through $60.00

Price per mg

Tablets 50 Count (1,000mg)$0.060/mg

30ml Vial (Liquid) (600mg)$0.080/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

Concentration and Formulation

Tablet Concentration50 Tablets (~20 mg/Tablet, laboratory reference use only)

Inactive IngredientsMicrocrystalline cellulose, Magnesium stearate, Dicalcium phosphate, Silicon dioxide,

Liquid Concentration And SolutionReference solution in PEG-400 / DMSO
Nominal analytical concentration (~20 mg/mL, laboratory reference use only)

Size

30ml Vial (Liquid)
Tablets 50 Count

Clear

For Research Use Only. Not for human or veterinary use

Key Documents

SDSTablet SDSSolution COA

SDS = Safety Data Sheet · COA = Certificate of Analysis

View All Documentation: Safety Data Sheets Certificates of Analysis

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Key Specifications

Parameter	Specification / Details
Primary Compound Name	Aminotadalafil (PDE5 Inhibitor Analog)
CAS Registry Number	385769-84-6
IUPAC Designation	(2R,8R)-6-amino-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Synonyms / Trade Names	Amino Tadalafil
PubChem CID	10178467
Molecular Formula	C₂₁H₁₈N₄O₄
Molar Mass / Weight	390.40 g/mol
Physical Appearance	White to off-white crystalline solid/powder (raw)
Solubility Profile	Soluble in DMSO and PEG 400. Insoluble in water.
Tested Purity	≥98% via HPLC
Liquid Concentration	20mg/mL in PEG-400 / DMSO (600mg per 30mL vial)
Tablet Strength	20mg per tablet (50 tablets, 1,000mg per bottle)
Alternative Formulations	Tadalafil (the parent approved compound)
Storage Guidelines	Store at room temperature (20°C to 25°C). For long-term storage of raw powder, keep at -20°C. Protect strictly from moisture and direct sunlight.
Estimated Shelf Life	24 months from manufacture date.
Safety Documentation	Standard SDS available for Aminotadalafil
Terms of Application	For laboratory research purposes only. Not for human or veterinary use. Investigated for its role as a phosphodiesterase type 5 (PDE5) inhibitor to evaluate localized smooth muscle relaxation and nitric oxide/cGMP signaling pathways in in-vitro vascular models.

Foundational Scientific Overview

Aminotadalafil is a prominent subject within the field of vascular hemodynamics and smooth muscle relaxation. Synthesized as an unapproved structural analog of tadalafil, it has become a staple for researchers examining the selective, reversible inhibition of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine monophosphate (cGMP) in-vitro.

At 4-Amino-Labs, we provide this compound in a highly purified format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity. Researchers seeking amino tadalafil research materials often prioritize quality and batch consistency.

The biochemical isolation and structural characterization of PDE5 analogs, focusing on their capacity to inhibit cGMP degradation in endothelial models, is well documented in pharmacological literature. See: Kukula, M., et al. (2011). "Structural and biochemical characterization of the novel PDE5 inhibitor aminotadalafil." Journal of Pharmaceutical and Biomedical Analysis, 54(3), 545-551.

Analytical Composition and Purity

Purity≥98%via HPLC

FormulaC21H18N4O4

Physical StateSupplied as 50-count tablets (~20mg/tablet) and as a ~20mg/mL solution in PEG 400 / DMSO (raw material: fine crystalline solid)

Investigational Pathways

PDE5 Inhibition

Evaluating the compound’s binding kinetics and competitive inhibition of the PDE5 enzyme active site.

cGMP Accumulation

Observing the downstream elevation of intracellular cGMP in isolated vascular smooth muscle tissues.

Vasodilation Models

Mapping the flux of calcium efflux leading to the relaxation of arterial walls in pre-clinical hemodynamic assays.

Endothelial Nitric Oxide Crosstalk

Investigating the synergistic enhancement of nitric oxide (NO) signaling pathways under oxidative stress.

Laboratory Handling and Stability

Thermal Regulation

Store in a controlled, cool, and desiccated environment.

Photostability

Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.

Contamination Control

Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely. Those looking for amino tadalafil for sale should ensure all intended use complies with laboratory regulations.

Analytical Composition & Purity Standards

Chemical Formula: C21H18N4O4
Physical State: Supplied as 50-count tablets (~20mg/tablet) and as a ~20mg/mL solution in PEG 400 / DMSO (raw material: fine crystalline solid)

Our Aminotadalafil undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 98%. This analytical rigor ensures the absence of cross-contaminants, providing a stable baseline for your in-vitro or pre-clinical models.

Investigational Pathways

Researchers utilizing Aminotadalafil typically focus on the following biochemical mechanisms while evaluating applications related to amino tadalafil liquid in controlled laboratory and analytical research settings.

PDE5 Inhibition: Evaluating the compound’s binding kinetics and competitive inhibition of the PDE5 enzyme active site.
cGMP Accumulation: Observing the downstream elevation of intracellular cGMP in isolated vascular smooth muscle tissues.
Vasodilation Models: Mapping the flux of calcium efflux leading to the relaxation of arterial walls in pre-clinical hemodynamic assays.
Endothelial Nitric Oxide Crosstalk: Investigating the synergistic enhancement of nitric oxide (NO) signaling pathways under oxidative stress.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of Aminotadalafil, the following storage parameters are recommended:

Thermal Regulation: Store in a controlled, cool, and desiccated environment.
Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.
Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.