Aminotadalafil
Inventory Status:
Availability: Available
Price range: $48.00 through $60.00
Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.
20mg/mL solution (600mg/30mL)
Tablet Concentration 50 Tablets (~20 mg/Tablet, laboratory reference use only)
Aminotadalafil is a potent phosphodiesterase type 5 (PDE5) inhibitor analog that continues to be one of the popular and demanded products available at 4-Amino-Labs. This multifunctional compound can be used to investigate PDE5 inhibition and associated biochemical processes in different experimental systems, as it is engineered for use in laboratory and pre-clinical research.
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Key Specifications
| Parameter | Specification / Details |
|---|---|
| Primary Compound Name | Aminotadalafil (PDE5 Inhibitor Analog) |
| CAS Registry Number | 385769-84-6 |
| IUPAC Designation | (2R,8R)-6-amino-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| Synonyms / Trade Names | Amino Tadalafil |
| PubChem CID | 10178467 |
| Molecular Formula | C21H18N4O4 |
| Molar Mass / Weight | 390.40 g/mol |
| Physical Appearance | White to off-white crystalline solid/powder (raw) |
| Solubility Profile | Soluble in DMSO and PEG 400. Insoluble in water. |
| Tested Purity | ≥98% via HPLC |
| Active Ingredient (Total) | [e.g., 600mg per 30mL vial or 60 capsules] |
| Dry / Powder Formulations | [e.g., 10mg or 20mg pressed capsules/tablets] |
| Liquid / Solution Concentrations | [e.g., 20mg/mL in a PEG 400 / DMSO carrier] |
| Alternative Formulations | Tadalafil (the parent approved compound) |
| Storage Guidelines | Store at room temperature (20°C to 25°C). For long-term storage of raw powder, keep at -20°C. Protect strictly from moisture and direct sunlight. |
| Estimated Shelf Life | 24 months from manufacture date. |
| Safety Documentation | Standard SDS available for Aminotadalafil |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated for its role as a phosphodiesterase type 5 (PDE5) inhibitor to evaluate localized smooth muscle relaxation and nitric oxide/cGMP signaling pathways in in-vitro vascular models. |
Foundational Scientific Overview
Aminotadalafil is a prominent subject within the field of vascular hemodynamics and smooth muscle relaxation. Synthesized as an unapproved structural analog of tadalafil, it has become a staple for researchers examining the selective, reversible inhibition of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine monophosphate (cGMP) in-vitro.
At 4 Amino Labs, we provide this compound in a highly purified format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity. Researchers seeking amino tadalafil research materials often prioritize quality and batch consistency.
Scientific Literature Reference: The biochemical isolation and structural characterization of PDE5 analogs, focusing on their capacity to inhibit cGMP degradation in endothelial models, is well documented in pharmacological literature. See: Kukula, M., et al. (2011). “Structural and biochemical characterization of the novel PDE5 inhibitor aminotadalafil.” Journal of Pharmaceutical and Biomedical Analysis, 54(3), 545-551.
Analytical Composition & Purity Standards
- Chemical Formula: C21H19N5O4
- Physical State: Fine Crystalline Solid
Our Aminotadalafil undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 99%. This analytical rigor ensures the absence of cross-contaminants, providing a stable baseline for your in-vitro or pre-clinical models.
Investigational Pathways
Researchers utilizing Aminotadalafil typically focus on the following biochemical mechanisms while evaluating applications related to amino tadalafil liquid in controlled laboratory and analytical research settings.
- PDE5 Inhibition: Evaluating the compound’s binding kinetics and competitive inhibition of the PDE5 enzyme active site.
- cGMP Accumulation: Observing the downstream elevation of intracellular cGMP in isolated vascular smooth muscle tissues.
- Vasodilation Models: Mapping the flux of calcium efflux leading to the relaxation of arterial walls in pre-clinical hemodynamic assays.
- Endothelial Nitric Oxide Crosstalk: Investigating the synergistic enhancement of nitric oxide (NO) signaling pathways under oxidative stress.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of Aminotadalafil, the following storage parameters are recommended:
- Thermal Regulation: Store in a controlled, cool, and desiccated environment.
- Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.
- Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.
Compliance & Safety Disclaimer
This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4 Amino Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely. Those looking for amino tadalafil for sale should ensure all intended use complies with laboratory regulations.
