IGF-1 LR3 1mg
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$70.00
Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.
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Key Specifications
| Parameter | Specification / Details |
|---|---|
| Primary Compound Name | IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) |
| CAS Registry Number | 143045-27-6 |
| Sequence / IUPAC Equivalent | 83-amino acid analogue of human IGF-1 (features a 13-amino-acid N-terminal extension and an Arginine substitution at position 3) |
| Synonyms / Trade Names | Long R3 IGF-1, LR3 IGF-1 |
| PubChem CID | N/A (Synthetic Protein Analogue) |
| Molecular Formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₆ |
| Molar Mass / Weight | ~9111.4 g/mol |
| Physical Appearance | White lyophilized (freeze-dried) solid/powder |
| Solubility Profile | Best reconstituted in dilute Acetic Acid (0.6% or 100mM) to preserve receptor affinity, or Bacteriostatic Water |
| Tested Purity | ≥99% via HPLC |
| Active Ingredient (Total) | 1mg IGF-1 LR3 per vial |
| Dry / Powder Formulations | Lyophilized cake/powder under vacuum |
| Liquid / Solution Concentrations | Requires reconstitution (e.g., adding 1mL of solvent yields 1,000mcg/mL) |
| Alternative Formulations | IGF-1 DES (a truncated, shorter half-life variant) |
| Storage Guidelines | Lyophilized: Store at -20°C for long-term stability. Reconstituted: Must be refrigerated at 2°C to 8°C (36°F to 46°F). |
| Estimated Shelf Life | 24+ months (lyophilized). 14 to 28 days (reconstituted and refrigerated). |
| Safety Documentation | Standard SDS available for IGF-1 LR3 Peptide |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. |
Foundational Scientific Overview
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-I) is a prominent subject within the field of cellular hyperplasia and muscle differentiation studies. Originally synthesized to investigate the modulation of the PI3K/AKT signaling pathway, it has become a staple for researchers examining cellular growth, survival, and proliferation in nutrient-deprived in-vitro environments.
At 4 Amino Labs, we provide this compound in a highly stable lyophilized powder to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity. This compound is frequently cited in peer-reviewed literature due to its well-documented interaction with the Type 1 IGF receptor and its significantly reduced affinity for IGF-binding proteins compared to standard IGF-1.
Analytical Composition & Purity Standards
- Chemical Formula: C400H625N111O115S6
- Physical State: White Lyophilized Solid
Our IGF-1 LR3 (1mg) undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 99%. This analytical rigor ensures the absence of residual solvents, heavy metals, or cross-contaminants, providing a stable baseline for your in-vitro or pre-clinical models.
Investigational Pathways
Researchers utilizing IGF-1 LR3 (1mg) typically focus on the following biochemical mechanisms:
- Cellular Hyperplasia: Evaluating the compound’s influence on the mitotic rate of satellite cells and myoblasts.
- PI3K/AKT Activation: Observing the downstream phosphorylation events that inhibit apoptosis and promote cellular survival.
- Metabolic Efficiency: Mapping the flux of glucose and amino acid transport across cellular membranes.
- Binding Protein Resistance: Investigating the agent’s extended half-life and sustained receptor activation due to reduced deactivation by IGFBPs.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of IGF-1 LR3 (1mg), the following storage parameters are recommended:
- Thermal Regulation: Store in a controlled, cool, and desiccated environment. Reconstitution requires a specific buffer (often 10mM HCl or acetic acid) before dilution with bacteriostatic water.
- Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.
- Hygroscopic Prevention: Ensure the seal is hermetic after every withdrawal to prevent moisture absorption and clumping.
- Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.
Compliance & Safety Disclaimer
This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4 Amino Lab does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.
