KPV (10mg)

Name: KPV (10mg)
Brand: 4-Amino-Labs
SKU: KPV-10MG
Price: 65.00 USD
Availability: InStock

Inventory Status:
Available

Product Details

AvailabilityIn stock

SKUKPV-10MG

CategoryShort-Chain Amino Acids

Brand4-Amino-Labs

SKU KPV-10MG Category Short-Chain Amino Acids Brand: 4-Amino-Labs

$65.00

Price per mg

Total (10mg)$6.50/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

Concentration and Formulation

Contents10mg per vial

FormLyophilized powder

Available

For Research Use Only. Not for human or veterinary use.

Key Documents

SDS COA

SDS = Safety Data Sheet · COA = Certificate of Analysis

View All Documentation: Safety Data Sheets Certificates of Analysis

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Key Specifications

Parameter	Specification / Details
Primary Compound Name	KPV (alpha-MSH Fragment)
CAS Registry Number	80082-62-8
Sequence / IUPAC	Lys-Pro-Val
Molecular Formula	C16H30N4O4
Molar Mass / Weight	342.43 g/mol
Physical Appearance	White lyophilized (freeze-dried) solid/powder
Solubility Profile	Highly soluble in Bacteriostatic Water and sterile water.
Tested Purity	≥98% via HPLC
Active Ingredient (Total)	10mg per vial
Dry / Powder Formulations	Lyophilized powder
Storage Guidelines	Lyophilized: Store at -20°C for long-term stability. Protect from light.Reconstituted: Must be refrigerated at 2°C to 8°C.
Estimated Shelf Life	24 months from manufacture date (lyophilized).
Terms of Application	For laboratory research purposes only. Not for human or veterinary use. Investigated for its potent anti-inflammatory properties, particularly evaluating the inhibition of NF-kB intracellular signaling pathways in mucosal and mast cell models.

Foundational Scientific Overview

KPV (10mg) is a paramount subject within the field of localized anti-inflammatory research and mucosal healing. Synthesized as a highly stable tripeptide (Lysine-Proline-Valine) representing the C-terminal sequence of alpha-melanocyte-stimulating hormone (ɑ-MSH), it serves researchers examining the profound down-regulation of pro-inflammatory cytokines without the melanogenic (pigment-inducing) side effects of full-length MSH.

At 4-Amino-Labs, we provide this highly purified compound to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity.

The biochemical capacity of the KPV tripeptide to enter intestinal and epithelial cells via the PepT1 transporter and strongly inhibit NF-ΚB activation is highly documented in gastroenterological literature. See: Dalmasso, G., et al. (2008). "PepT1-mediated epithelial transport of the antimicrobial peptide KPV suppresses intestinal inflammation." Gastroenterology, 134(1), 166-178.

Analytical Composition and Purity

Purity≥98%via HPLC

FormulaC16H30N4O4

Physical StateWhite Lyophilized Solid

Investigational Pathways

NF-kappaB Inhibition

Evaluating the compound’s capacity to translocate into the nucleus and directly block the transcription of pro-inflammatory cytokines (IL-6, IL-8, TNF-$\alpha$).

Mucosal Healing

Observing the accelerated repair of epithelial barriers in isolated intestinal or dermal cell cultures under induced inflammatory stress.

Antimicrobial Modeling

Mapping the peptide's targeted fungicidal and bacteriostatic effects in specific pathogen-exposed cellular assays.

Laboratory Handling and Stability

Thermal Regulation

Store in a strictly controlled, refrigerated, and desiccated environment.

Photostability

Protect from direct UV exposure; storage in an opaque container is advised.

Contamination Control

Utilize sterilized instruments and work within a laminar flow hood where possible.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

Analytical Composition & Purity Standards

Chemical Formula: C16H30N4O4
Physical State: White Lyophilized Solid

Our KPV undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 98%.

Investigational Pathways

Researchers utilizing KPV typically focus on the following biochemical mechanisms:

NF-kappaB Inhibition: Evaluating the compound’s capacity to translocate into the nucleus and directly block the transcription of pro-inflammatory cytokines (IL-6, IL-8, TNF-$\alpha$).
Mucosal Healing: Observing the accelerated repair of epithelial barriers in isolated intestinal or dermal cell cultures under induced inflammatory stress.
Antimicrobial Modeling: Mapping the peptide’s targeted fungicidal and bacteriostatic effects in specific pathogen-exposed cellular assays.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of KPV, the following storage parameters are recommended:

Thermal Regulation: Store in a strictly controlled, refrigerated, and desiccated environment.
Photostability: Protect from direct UV exposure; storage in an opaque container is advised.
Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible.