Humanin (10mg)

Name: Humanin (10mg)
Brand: 4-Amino-Labs
SKU: HUMANIN-10MG
Price: 80.00 USD
Availability: InStock

Inventory Status:
Available

Product Details

AvailabilityIn stock

SKUHUMANIN-10MG

CategoriesBioregulators, Short-Chain Amino Acids

Brand4-Amino-Labs

SKU HUMANIN-10MG Categories Bioregulators, Short-Chain Amino Acids Brand: 4-Amino-Labs

$80.00

Price per mg

Total (10mg)$8.00/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

Concentration and Formulation

Contents10mg per vial

FormLyophilized powder

Available

For Research Use Only. Not for human or veterinary use.

Key Documents

SDS COA

SDS = Safety Data Sheet · COA = Certificate of Analysis

View All Documentation: Safety Data Sheets Certificates of Analysis

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Key Specifications

Parameter	Specification / Details
Primary Compound Name	Humanin (Mitochondrial Derived Peptide)
CAS Registry Number	330936-69-1
Sequence / IUPAC	Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula	C119H204N34O32S2
Molar Mass / Weight	2687.3 g/mol
Physical Appearance	White lyophilized (freeze-dried) solid/powder
Solubility Profile	Highly soluble in Bacteriostatic Water and sterile water.
Tested Purity	≥98% via HPLC
Active Ingredient (Total)	10mg per vial
Dry / Powder Formulations	Lyophilized powder
Storage Guidelines	Lyophilized: Store at -20°C for long-term stability. Protect from light.Reconstituted: Must be refrigerated at 2°C to 8°C.
Estimated Shelf Life	24 months from manufacture date (lyophilized).
Terms of Application	For laboratory research purposes only. Not for human or veterinary use. Investigated for potent intracellular neuroprotection, specifically evaluating its capacity to suppress BAX-induced apoptosis in cellular stress models.

Foundational Scientific Overview

Humanin (10mg) is a paramount subject within the field of mitochondrial bioenergetics and neuroprotection. As a 24-amino acid mitochondrial-derived peptide (MDP), it has become a staple for researchers examining the profound inhibition of apoptotic cascades, cellular survival under oxidative stress, and the mitigation of amyloid-beta toxicity in neurodegenerative models.

At 4-Amino-Labs, we provide this delicate sequence in a highly purified format to ensure experimental reproducibility in sensitive neurological assays.

The biochemical discovery of Humanin as a neuroprotective factor capable of abolishing neuronal cell death induced by multiple Alzheimer's disease genes is a landmark in neurobiology. See: Hashimoto, Y., et al. (2001). "A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta." Proceedings of the National Academy of Sciences, 98(11), 6336-6341.

Analytical Composition and Purity

Purity≥98%via HPLC

FormulaC119H204N34O32S2

Physical StateWhite Lyophilized Solid

Investigational Pathways

BAX Inhibition

Evaluating the compound’s binding to the pro-apoptotic BAX protein, preventing its translocation to the mitochondria, and halting cell death.

Amyloid-Beta Resistance

Observing the maintenance of cellular viability in hippocampal neuron cultures exposed to neurotoxic amyloid-beta plaques.

Metabolic Cytoprotection

Mapping the preservation of ATP synthesis and mitochondrial membrane potential under severe oxidative or ischemic stress.

Laboratory Handling and Stability

Thermal Regulation

Store in a strictly controlled, refrigerated, and desiccated environment. Unmixed powder is best preserved at -20°C.

Photostability

Protect from direct UV exposure; storage in an opaque container is strictly advised.

Contamination Control

Utilize sterilized instruments and work within a laminar flow hood where possible.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

Analytical Composition & Purity Standards

Chemical Formula: C119H204N34O32S2
Physical State: White Lyophilized Solid

Our Humanin undergoes a multifaceted verification process via independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 98%.

Investigational Pathways

Researchers utilizing Humanin typically focus on the following biochemical mechanisms:

BAX Inhibition: Evaluating the compound’s binding to the pro-apoptotic BAX protein, preventing its translocation to the mitochondria, and halting cell death.
Amyloid-Beta Resistance: Observing the maintenance of cellular viability in hippocampal neuron cultures exposed to neurotoxic amyloid-beta plaques.
Metabolic Cytoprotection: Mapping the preservation of ATP synthesis and mitochondrial membrane potential under severe oxidative or ischemic stress.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of Humanin, the following storage parameters are recommended:

Thermal Regulation: Store in a strictly controlled, refrigerated, and desiccated environment. Unmixed powder is best preserved at -20°C.
Photostability: Protect from direct UV exposure; storage in an opaque container is strictly advised.
Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible.