Humanin (10mg)
Inventory Status:
Out of stock
$80.00
Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.
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Key Specifications
| Category | Parameter | Specification / Details |
|---|---|---|
| Identification & Nomenclature | Primary Compound Name | Humanin (Mitochondrial Derived Peptide) |
| CAS Registry Number | 330936-69-1 | |
| Sequence / IUPAC | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala | |
| Chemical & Physical Properties | Molecular Formula | C119H204N34O32S2 |
| Molar Mass / Weight | 2687.3 g/mol | |
| Physical Appearance | White lyophilized (freeze-dried) solid/powder | |
| Solubility Profile | Highly soluble in Bacteriostatic Water and sterile water. | |
| Product Specifications | Tested Purity | ≥98% via HPLC |
| Active Ingredient (Total) | 10mg per vial | |
| Dry / Powder Formulations | Lyophilized powder | |
| Handling & Logistics | Storage Guidelines | Lyophilized: Store at -20°C for long-term stability. Protect from light.Reconstituted: Must be refrigerated at 2°C to 8°C. |
| Estimated Shelf Life | 24 months from manufacture date (lyophilized). | |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated for potent intracellular neuroprotection, specifically evaluating its capacity to suppress BAX-induced apoptosis in cellular stress models. |
Foundational Scientific Overview
Humanin (10mg) is a paramount subject within the field of mitochondrial bioenergetics and neuroprotection. As a 24-amino acid mitochondrial-derived peptide (MDP), it has become a staple for researchers examining the profound inhibition of apoptotic cascades, cellular survival under oxidative stress, and the mitigation of amyloid-beta toxicity in neurodegenerative models.
At 4 Amino Labs, we provide this delicate sequence in a highly purified format to ensure experimental reproducibility in sensitive neurological assays.
Scientific Literature Reference: The biochemical discovery of Humanin as a neuroprotective factor capable of abolishing neuronal cell death induced by multiple Alzheimer’s disease genes is a landmark in neurobiology. See: Hashimoto, Y., et al. (2001). “A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta.” Proceedings of the National Academy of Sciences, 98(11), 6336-6341.
Analytical Composition & Purity Standards
- Chemical Formula: C119H204N34O32S2
- Physical State: White Lyophilized Solid
Our Humanin undergoes a multifaceted verification process via independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≧ 99%.
Investigational Pathways
Researchers utilizing Humanin typically focus on the following biochemical mechanisms:
- BAX Inhibition: Evaluating the compound’s binding to the pro-apoptotic BAX protein, preventing its translocation to the mitochondria, and halting cell death.
- Amyloid-Beta Resistance: Observing the maintenance of cellular viability in hippocampal neuron cultures exposed to neurotoxic amyloid-beta plaques.
- Metabolic Cytoprotection: Mapping the preservation of ATP synthesis and mitochondrial membrane potential under severe oxidative or ischemic stress.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of Humanin, the following storage parameters are recommended:
- Thermal Regulation: Store in a strictly controlled, refrigerated, and desiccated environment. Unmixed powder is best preserved at -20°C.
- Photostability: Protect from direct UV exposure; storage in an opaque container is strictly advised.
- Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible.
Compliance & Safety Disclaimer
This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4 Amino Lab does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.
