GW501516 (Cardarine)

Inventory Status:

Out of stock

Product Details
AvailabilityOut of stock
SKUGW501516
SKU GW501516 Category Tags , , Brand:

$58.00

Price per mg
30ml Vial (Liquid) (750mg)$0.077/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

Concentration and Formulation
Contents750mg per 30mL vial
Concentration25mg/mL in a PEG 400 / Ethanol carrier
For Research Use Only. Not for human or veterinary use.
Key Documents
SDS = Safety Data Sheet  ·  COA = Certificate of Analysis

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Key Specifications

ParameterSpecification / Details
Primary Compound NameGW501516 (PPARδ Agonist)
CAS Registry Number317318-70-0
IUPAC Designation2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
Synonyms / Trade NamesCardarine, Endurobol, GSK-516
PubChem CID9803963
Molecular FormulaC₂₁H₁₈F₃NO₃S₂
Molar Mass / Weight453.50 g/mol
Physical AppearanceWhite to off-white crystalline powder (raw) / Clear or slightly tinted liquid (suspended)
Solubility ProfileSoluble in DMSO, Ethanol, and Propylene Glycol/PEG 400. Insoluble in water.
Tested Purity≥99% via HPLC
Active Ingredient (Total)750mg per 30mL vial
Dry / Powder FormulationsN/A (Liquid suspension)
Liquid / Solution Concentrations25mg/mL in a PEG 400 / Ethanol carrier
Alternative FormulationsGW0742 (Fitorine - a closely related PPARδ agonist)
Storage GuidelinesStore at room temperature (20°C to 25°C). Protect strictly from moisture, heat, and direct sunlight.
Estimated Shelf Life24 months from manufacture date.
Safety DocumentationStandard SDS available for GW501516
Terms of ApplicationFor laboratory research purposes only. Not for human or veterinary use. Investigated for its role as a high-affinity PPARδ agonist to evaluate fatty acid oxidation, mitochondrial biogenesis, and metabolic signaling in in-vitro models.

Foundational Scientific Overview

Foundational Scientific Overview

GW501516 (Cardarine) is a paramount subject within the field of cellular bioenergetics and exercise mimetic pharmacology. As a highly potent peroxisome proliferator-activated receptor delta (PPARδ) agonist, it has become a staple for researchers examining the shift from glucose oxidation to lipid oxidation, mitochondrial biogenesis, and skeletal muscle fiber type switching.

At 4-Amino-Labs, we provide this complex in a highly purified format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity.

The biochemical pathway of PPARδ acting as an "exercise mimetic" by fundamentally altering fuel preference at the mitochondrial level is a cornerstone of modern metabolic research. See: Narkar, V. A., et al. (2008). "AMPK and PPARdelta agonists are exercise mimetics." Cell, 134(3), 405-415.

Analytical Composition and Purity

Purity≥99%via HPLC
FormulaC21H18F3NO3S2
Physical StateClear or slightly tinted solution, 25mg/mL in a PEG 400 / Ethanol carrier (raw material: fine white crystalline solid)

Investigational Pathways

Substrate Preference Shifting
Evaluating the compound’s capacity to drastically upregulate fatty acid oxidation over glycolysis in myotube cultures.
AMPK Crosstalk
Observing the synergistic activation pathways between PPARδ and AMP-activated protein kinase.
Mitochondrial Biogenesis
Mapping the increased density and efficiency of mitochondria in isolated skeletal muscle models.
Fiber Type Reprogramming
Investigating the transcriptional shift from fast-twitch (Type IIx) to slow-twitch (Type I) muscle fibers in-vitro.

Laboratory Handling and Stability

Thermal Regulation
Store in a controlled, cool, and desiccated environment.
Photostability
Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised.
Contamination Control
Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

Analytical Composition & Purity Standards

  • Chemical Formula: C21H18F3NO3S2
  • Physical State: Clear or slightly tinted solution, 25mg/mL in a PEG 400 / Ethanol carrier (raw material: fine white crystalline solid)

Our GW501516 undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) to ensure a purity threshold of ≥  99%. This analytical rigor ensures the absence of cross-contaminants or heavy metal degradation products.

Investigational Pathways

Researchers utilizing GW501516 typically focus on the following biochemical mechanisms:

  • Substrate Preference Shifting: Evaluating the compound’s capacity to drastically upregulate fatty acid oxidation over glycolysis in myotube cultures.
  • AMPK Crosstalk: Observing the synergistic activation pathways between PPARδ and AMP-activated protein kinase.
  • Mitochondrial Biogenesis: Mapping the increased density and efficiency of mitochondria in isolated skeletal muscle models.
  • Fiber Type Reprogramming: Investigating the transcriptional shift from fast-twitch (Type IIx) to slow-twitch (Type I) muscle fibers in-vitro.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of GW501516, the following storage parameters are recommended:

  • Thermal Regulation: Store in a controlled, cool, and desiccated environment.
  • Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised.
  • Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.

Compliance & Safety Disclaimer

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

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GW501516 (Cardarine)