AOD-9604 (5mg)

Name: AOD-9604 (5mg)
Brand: 4-Amino-Labs
SKU: AOD9604-5MG
Price: 45.00 USD
Availability: InStock

Inventory Status:
Available

Product Details

AvailabilityIn stock

SKUAOD9604-5MG

CategoryShort-Chain Amino Acids

Brand4-Amino-Labs

SKU AOD9604-5MG Category Short-Chain Amino Acids Tags aod, aod 9604, aod9604 Brand: 4-Amino-Labs

$45.00

Price per mg

Total (5mg)$9.00/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

Concentration and Formulation

Contents5mg per vial

FormLyophilized powder

Available

For Research Use Only. Not for human or veterinary use.

Key Documents

SDS COA

SDS = Safety Data Sheet · COA = Certificate of Analysis

View All Documentation: Safety Data Sheets Certificates of Analysis

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Key Specifications

Parameter	Specification / Details
Primary Compound Name	AOD-9604 (HGH Fragment 177-191)
CAS Registry Number	221231-10-3
Sequence / IUPAC	Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular Formula	C78H123N23O23S2
Molar Mass / Weight	1815.1 g/mol
Physical Appearance	White lyophilized (freeze-dried) solid/powder
Solubility Profile	Highly soluble in Bacteriostatic Water and sterile water.
Tested Purity	≥98% via HPLC
Active Ingredient (Total)	5mg per vial
Dry / Powder Formulations	Lyophilized powder
Storage Guidelines	Lyophilized: Store at -20°C for long-term stability. Protect from light.Reconstituted: Must be refrigerated at 2°C to 8°C.
Estimated Shelf Life	24 months from manufacture date (lyophilized).
Terms of Application	For laboratory research purposes only. Not for human or veterinary use. Investigated as a C-terminal peptide fragment of hGH to evaluate beta-3 adrenergic receptor modulation and targeted lipolysis in in-vitro adipocyte assays, specifically without inducing IGF-1 or altering glucose homeostasis.

Foundational Scientific Overview

AOD-9604 (5mg) is a highly specialized subject within the field of localized lipolysis and beta-adrenergic receptor modulation. Synthesized as a modified C-terminal fragment of human Growth Hormone (tyrosine-hGH 177-191), it has become a staple for researchers examining fat catabolism without the associated anabolism, IGF-1 elevation, or insulin resistance typical of full-length GH.

At 4-Amino-Labs, we provide this highly purified peptide fragment to ensure experimental reproducibility across varied lipid metabolic assays.

The biochemical isolation of the lipolytic domain of human growth hormone, proving its capacity to upregulate fat oxidation independently of the growth hormone receptor, is a cornerstone of lipolytic research. See: Heffernan, M. A., et al. (2001). "The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice." Endocrinology, 142(12), 5182-5189.

Analytical Composition and Purity

Purity≥98%via HPLC

FormulaC78H123N23O23S2

Physical StateWhite Lyophilized Solid

Investigational Pathways

Beta-3 Adrenergic Sensitization

Evaluating the compound’s capacity to upregulate $\beta_3$-AR expression in isolated pre-adipocyte models.

Hormone-Sensitive Lipase (HSL) Activation

Observing the direct triggering of triglyceride hydrolysis without cAMP elevation.

Lipogenesis Inhibition

Mapping the compound's capacity to halt the conversion of glucose and free fatty acids into stored lipids.

Chondrogenic Repair

Investigating secondary applications regarding the upregulation of proteoglycan and collagen synthesis in joint tissue assays.

Laboratory Handling and Stability

Thermal Regulation

Store in a strictly controlled, refrigerated, and desiccated environment.

Photostability

Protect from direct UV exposure; storage in an opaque container is advised.

Contamination Control

Utilize sterilized instruments and work within a laminar flow hood where possible.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

Analytical Composition & Purity Standards

Chemical Formula: C78H123N23O23S2
Physical State: White Lyophilized Solid

Our AOD-9604 undergoes a multifaceted verification process via independent High-Performance Liquid Chromatography (HPLC) to ensure a purity threshold of ≥ 98%, guaranteeing the absence of elongated or functionally altered sequences.

Investigational Pathways

Researchers utilizing AOD-9604 typically focus on the following biochemical mechanisms:

Beta-3 Adrenergic Sensitization: Evaluating the compound’s capacity to upregulate $\beta_3$-AR expression in isolated pre-adipocyte models.
Hormone-Sensitive Lipase (HSL) Activation: Observing the direct triggering of triglyceride hydrolysis without cAMP elevation.
Lipogenesis Inhibition: Mapping the compound’s capacity to halt the conversion of glucose and free fatty acids into stored lipids.
Chondrogenic Repair: Investigating secondary applications regarding the upregulation of proteoglycan and collagen synthesis in joint tissue assays.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of AOD-9604, the following storage parameters are recommended:

Thermal Regulation: Store in a strictly controlled, refrigerated, and desiccated environment.
Photostability: Protect from direct UV exposure; storage in an opaque container is advised.
Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible.