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Price range: $48.00 through $60.00
Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.
| Parameter | Specification / Details |
|---|---|
| Primary Compound Name | Endoxifen, (Z)-isomer (Non-Steroidal SERM) |
| CAS Registry Number | 112093-28-4 ((Z)-isomer), 110025-28-0 (E/Z mixture) |
| IUPAC Designation | 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol |
| Synonyms | Z-Endoxifen, 4-Hydroxy-N-desmethyltamoxifen, N-Desmethyl-4-hydroxytamoxifen |
| Molecular Formula | C25H27NO2 |
| Molar Mass / Weight | 373.49 g/mol |
| Compound Class | Triphenylethylene derivative / active tamoxifen metabolite |
| Physical Appearance | White tablet / Clear, colorless to pale yellow solution (raw material: white to off-white powder) |
| Solubility Profile | Soluble in DMSO, Ethanol and PEG-400. Practically insoluble in water. |
| Tested Purity | ≥98% via HPLC |
| Tablet Concentration | ~20mg per tablet, 50 tablets (1,000mg total) |
| Inactive Ingredients (Tablets) | Microcrystalline cellulose, Magnesium stearate, Dicalcium phosphate, Silicon dioxide |
| Liquid / Solution Concentration | 20mg/mL in a PEG-400 / Ethanol (90:10 v/v) carrier, 30mL (600mg total) |
| Related Compounds | Tamoxifen (parent compound), 4-Hydroxytamoxifen, Enclomiphene Citrate |
| Storage Guidelines | Tablets: cool, dry, protected from light; 2–8°C for long-term storage. Liquid: controlled room temperature (20–25°C), tightly capped, protected from light and ignition sources; do not refrigerate. |
| Estimated Shelf Life | 24 months from manufacture date when stored as directed. |
| Safety Documentation | SDS available for Endoxifen 20 mg Tablets and Endoxifen 20 mg/mL Solution |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated as a high-affinity, CYP2D6-independent estrogen receptor (ERα/ERβ) ligand in cellular and biochemical models. |
Endoxifen (4-hydroxy-N-desmethyltamoxifen) is a prominent subject within the field of selective estrogen receptor modulators (SERMs). As the principal active metabolite of tamoxifen, it has become a key reference compound for researchers examining estrogen receptor signaling, endocrinology, and hormone-responsive cell models. Unlike tamoxifen, endoxifen does not require CYP2D6 bioactivation, removing a major source of metabolic variability from experimental designs.
At 4-Amino-Labs, we provide this compound in 20mg tablets (50 count) and a 20mg/mL liquid solution (30mL, PEG-400/ethanol 90:10) to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity. Endoxifen is widely cited in peer-reviewed literature for its high-affinity, well-documented interaction with estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ).
Endoxifen is supplied strictly as a Research Use Only (RUO) laboratory reference compound for in-vitro and pre-clinical investigation. It is not a drug, dietary supplement, or approved medicine, and is not for human or veterinary use. Endoxifen is classified as a suspected carcinogen and reproductive toxicant (see Safety Data Sheet): persons who are pregnant, breast-feeding, or may become pregnant should not handle this product. Handle only by qualified personnel with appropriate protective equipment, and dispose of waste through a licensed contractor.
Our Endoxifen undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 98%, including confirmation of the (Z)-isomer. This analytical rigor ensures the absence of residual solvents, heavy metals, or cross-contaminants, providing a stable baseline for your in-vitro or pre-clinical models. Researchers looking to buy endoxifen tablets often prioritize verified purity and consistent quality standards.
Researchers utilizing Endoxifen typically focus on the following biochemical mechanisms:
Endoxifen is commonly examined in molecular endocrinology and estrogen receptor research, particularly in studies involving:
Because it is supplied in its active, post-metabolic form, endoxifen allows researchers to isolate SERM activity from the confounding effects of variable tamoxifen metabolism.
To maintain the molecular integrity of Endoxifen, the following storage parameters are
recommended:
This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.
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