MK-677 (Ibutamoren)
Inventory Status:
Availability: Available
$67.00
Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.
25mg/ml solution (750mg/30mL)
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Key Specifications
| Parameter | Specification / Details |
|---|---|
| Primary Compound Name | Ibutamoren Mesylate (MK-677) |
| CAS Registry Number | 159752-10-0 (Mesylate salt), 159634-47-6 (Free base) |
| IUPAC Designation | 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide;methanesulfonic acid |
| Synonyms / Trade Names | Nutrobal, Ibutamoren, MK-677 |
| PubChem CID | 178024 (Mesylate), 9939050 (Free base) |
| Molecular Formula | C28H40N4O8S2 (Mesylate) |
| Molar Mass / Weight | 624.8 g/mol (Mesylate) |
| Physical Appearance | White to off-white crystalline powder (raw) / Clear or slightly tinted liquid (suspended) |
| Solubility Profile | Soluble in Water, DMSO, Ethanol, and Propylene Glycol. |
| Tested Purity | ≥98% via HPLC |
| Active Ingredient (Total) | 750mg per 30mL vial |
| Dry / Powder Formulations | N/A (Liquid suspension) |
| Liquid / Solution Concentrations | 25mg/mL in a PEG 400 / Ethanol or Water/Ethanol carrier |
| Alternative Formulations | MK-777 (Acetamoren - the acetylated derivative we mapped earlier) |
| Storage Guidelines | Store at room temperature (20°C to 25°C). Protect strictly from moisture, heat, and direct sunlight. |
| Estimated Shelf Life | 24 months from manufacture date. |
| Safety Documentation | Standard SDS available for Ibutamoren Mesylate |
| Terms of Application | For laboratory research purposes only. Not for human or veterinary use. Investigated for its role as a potent, long-acting, non-peptide agonist of the ghrelin receptor (GHSR1a) to evaluate the stimulation of the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) axis in in-vitro and cellular models. |
Foundational Scientific Overview
MK-677 (Ibutamoren) is a paramount subject within the field of neuroendocrinology and growth hormone research. As a potent, non-peptide agonist of the ghrelin receptor (GHSR1a), it has become a staple for researchers examining the upstream regulation of the somatotropic axis, insulin-like growth factor 1 (IGF-1) secretion, and nitrogen retention.
At 4 Amino Labs, we provide this compound in a highly purified format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity.
Scientific Literature Reference: The biochemical pathway of non-peptide secretagogues mimicking ghrelin to stimulate sustained, pulsatile growth hormone release without elevating cortisol is a cornerstone of endocrine research. See: Smith, R. G., et al. (1997). “A nonpeptide growth hormone secretagogue.” Science, 276(5319), 1706-1709.
Analytical Composition & Purity Standards
- Chemical Formula: C27H36N4O5S
- Physical State: Fine White to Off-White Crystalline Powder
Our MK-677 undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) to ensure a purity threshold of ≥ 99%.
Investigational Pathways
Researchers utilizing MK-677 typically focus on the following biochemical mechanisms:
- GHSR1a Agonism: Evaluating the compound’s binding to the ghrelin receptor and the subsequent intracellular calcium flux in isolated pituitary cellular models.
- Somatotropic Pulsatility: Observing the downstream elevation of Growth Hormone (GH) and IGF-1 secretion without disrupting endogenous pulsatile rhythms.
- Osteoblast Genesis: Mapping the flux of bone turnover markers and bone mineral density in osteoporotic tissue assays.
- Metabolic Efficiency: Investigating the agent’s capacity to alter basal metabolic rates and induce transient insulin resistance in-vitro.
Laboratory Handling & Stability Protocol
To maintain the molecular integrity of MK-677, the following storage parameters are recommended:
- Thermal Regulation: Store in a controlled, cool, and desiccated environment.
- Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised.
- Contamination Control: Utilize sterilized instruments and work within a laminar flow hood where possible to maintain sample sterility.
Compliance & Safety Disclaimer
This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4 Amino Lab does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.
