Orforglipron

Inventory Status:
Available

Product Details

AvailabilityIn stock

SKUORFO

CategoriesAnalytical Reagents, Best Sellers

Brand4-Amino-Labs

SKU ORFO Categories Analytical Reagents, Best Sellers Tags oral glp-1, orfor Brand: 4-Amino-Labs

Price range: $95.00 through $145.00

Price per mg

Tablets 50 Count (600mg)$0.242/mg

30ml Vial (Liquid) (360mg)$0.264/mg

Strict Regulatory Notice: This agent is synthesized strictly for laboratory-based research and analytical purposes. It is not intended for human or veterinary use, nor for medical, household, or cosmetic applications. Please review our Terms of Service thoroughly before finalizing your acquisition.

GLP compounds payment notice

GLP compounds are not eligible for credit card purchases. When a GLP product is in your cart, all credit card payment options are automatically removed. Please choose another payment method, such as ACH, cryptocurrency, or Zelle.

Orforglipron is supplied as a high-purity analytical reference compound for non-clinical laboratory research applications.

This material is intended strictly for in-vitro biochemical and analytical studies.

Concentration and Formulation

Tablet Concentration50 Tablets (~12 mg/Tablet, laboratory reference use only)

Inactive IngredientsMicrocrystalline cellulose, Magnesium stearate, Dicalcium phosphate, Silicon dioxide,

Liquid Concentration And SolutionReference solution in PEG-400 / DMSO
Nominal analytical concentration (~12 mg/mL, laboratory reference use only)

Size

30ml Vial (Liquid)
Tablets 50 Count

Clear

For Research Use Only. Not for human or veterinary use

Key Documents

SDSTablet SDSSolution COA

SDS = Safety Data Sheet · COA = Certificate of Analysis

View All Documentation: Safety Data Sheets Certificates of Analysis

Guaranteed Safe Checkout:

Key Specifications

Parameter	Specification / Details
Primary Compound Name	Orforglipron (Non-peptide GLP-1 Receptor Agonist)
CAS Registry Number	2212020-52-3
IUPAC Designation	3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one
Synonyms / Trade Names	LY3502970, OWL833
PubChem CID	137319706
Molecular Formula	C₄₈H₄₈F₂N₁₀O₅
Molar Mass / Weight	882.97 g/mol
Physical Appearance	White to off-white crystalline powder (raw) / Clear liquid (suspended)
Solubility Profile	Soluble in DMSO (up to 125 mg/mL) and PEG 400. Insoluble in water.
Tested Purity	≥98% via HPLC
Alternative Formulations	Danuglipron (closely related small-molecule GLP-1RA)
Storage Guidelines	Powder: Store at -20°C for long-term stability. Liquid Suspension: Store at room temperature (20°C to 25°C). Protect from moisture and light.
Estimated Shelf Life	24 months from manufacture date.
Safety Documentation	Standard SDS available for Orforglipron
Terms of Application	For laboratory research purposes only. Not for human or veterinary use. Investigated as a biased ligand for the GLP-1 receptor, prioritizing G-protein activation and cyclic AMP (cAMP) accumulation over β-arrestin recruitment in cellular assays.
	Sources https://pubchem.ncbi.nlm.nih.gov/compound/Orforglipron

Foundational Scientific Overview

Orforglipron is a prominent subject within the field of metabolic research and endocrinology. Originally synthesized to investigate the modulation of incretin pathways, it has become a staple for researchers examining non-peptide, orally bioavailable glucagon-like peptide-1 (GLP-1) receptor agonists.

At 4-Amino-Labs, we provide this compound in a high-purity format to ensure experimental reproducibility. By maintaining rigorous measurement standards, we provide the consistency required for longitudinal data integrity. This compound is frequently cited in peer-reviewed literature due to its well-documented interaction with the GLP-1 receptor and subsequent cyclic AMP (cAMP) accumulation in pancreatic beta-cell models.

Analytical Composition and Purity

Purity≥98%via HPLC

FormulaC48H48F2N10O5

Physical StateSupplied as 50-count tablets and as a 30mL solution (raw material: fine crystalline solid)

Investigational Pathways

Receptor Kinetics

Evaluating the compound’s non-peptide binding affinity and biased agonism at the GLP-1 receptor.

Insulinotropic Activity

Observing glucose-dependent insulin secretion pathways in isolated pancreatic islets.

Gastric Modulation

Mapping the mechanisms of delayed gastric emptying and gastrointestinal motility in pre-clinical models.

Cellular Viability

Investigating the agent’s role in beta-cell proliferation and resistance to apoptosis under lipotoxic stress.

Laboratory Handling and Stability

Thermal Regulation

Store in a controlled, cool, and desiccated environment.

Photostability

Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.

Hygroscopic Prevention

Ensure the seal is hermetic after every withdrawal to prevent moisture absorption and clumping.

Contamination Control

Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.

Compliance and Safety

This substance is provided exclusively for in-vitro laboratory research and pre-clinical developmental testing. 4-Amino-Labs does not condone or authorize the use of this product in any clinical setting or for personal consumption. Misuse of laboratory chemicals carries significant health risks. By purchasing, the researcher acknowledges the inherent risks and confirms they possess the necessary equipment and expertise to handle these materials safely.

Analytical Composition & Purity Standards

Chemical Formula: C48H48F2N10O5
Physical State: Supplied as 50-count tablets and as a 30mL solution (raw material: fine crystalline solid)

Our Orforglipron undergoes a multifaceted verification process. Each batch is subjected to independent High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure a purity threshold of ≥ 98%. This analytical rigor ensures the absence of residual solvents, heavy metals, or cross-contaminants, providing a stable baseline for your in-vitro or pre-clinical models.

Investigational Pathways

Researchers utilizing Orforglipron typically focus on the following biochemical mechanisms:

Receptor Kinetics: Evaluating the compound’s non-peptide binding affinity and biased agonism at the GLP-1 receptor.
Insulinotropic Activity: Observing glucose-dependent insulin secretion pathways in isolated pancreatic islets.
Gastric Modulation: Mapping the mechanisms of delayed gastric emptying and gastrointestinal motility in pre-clinical models.
Cellular Viability: Investigating the agent’s role in beta-cell proliferation and resistance to apoptosis under lipotoxic stress.

Laboratory Handling & Stability Protocol

To maintain the molecular integrity of Orforglipron, the following storage parameters are recommended:

Thermal Regulation: Store in a controlled, cool, and desiccated environment.
Photostability: Protect from direct UV exposure; storage in an opaque container or dark cabinet is advised to prevent photodegradation.
Hygroscopic Prevention: Ensure the seal is hermetic after every withdrawal to prevent moisture absorption and clumping.
Contamination Control: Use sterilized instruments and work within a laminar-flow hood, when possible, to maintain sample sterility.