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CAS: 1379686-29-9
SR-9011 is a second-generation activator of the Rev-ErbA receptors which are found abundantly in liver, skeletal muscle, fat tissue, and the brain, where they function to promote normal development and circadian regulation of these tissues.
1. Reductions in body fat and improved blood lipid/glucose profiles [1]
2. Anticancer function [2]
3. Increased basal oxygen consumption in muscle [3]
4. Decreased lipogenesis (ie. fat storage in cells) [2]
5. Increased mitochondrial content in muscle cells [4]
6. Lowers inflammatory cytokine levels in microglia (immune cells in the brain) [5], [6]
Although it may seem surprising, there is a strong link between your internal circadian rhythm and proper metabolic function. In mammals, almost all tissues display a self-sustaining molecular “pacemaker” that is responsible for aligning rhythms in various physiological functions.
Physiological processes involving metabolism and behavior, e.g., sleep/wake cycles, activity/rest cycles, are generally organized on a cycle of ~24 hours controlled by a circadian rhythm. The nuclear receptors Rev-ErbA and Rev-ErbB regulate the levels of core “clock proteins” and thus help to modulate the circadian rhythm.
Blood glucose levels and hormones such as insulin and glucagon also exhibit daily variations. Alterations in circadian rhythms are associated with metabolic disturbances and pathologies such as obesity and diabetes. The molecular components of these internal clocks and their regulatory mechanisms are well established. Among the different clock genes, Rev-ErbA is considered one of the key links between circadian rhythms and metabolism specifically.
Desynchronization of the body’s clock or misalignment between circadian rhythm and metabolism contributes to the development of chronic metabolic and cardiovascular diseases [7]. In experimental models, knockout and mutations in clock genes that lead to the disruption of circadian rhythms have revealed the tight link between the circadian clock, fat tissue and metabolism [8].
Modulation of Rev-ErbA/B gene activity by synthetic activators (eg, SR9009 and SR9011) changes the levels of genes involved in fat and glucose metabolism and thus plays an essential role in maintaining the energy balance. Effects of SR9009 and SR9011 observed via in vitro and in animal studies are the following: increased basal oxygen consumption, decreased lipogenesis (ie. fat synthesis), decreased cholesterol and bile acid synthesis in the liver, increased mitochondrial content (ie. stronger oxidative capacity), increased glucose and fatty acid oxidation in the skeletal muscle, and decreased lipid storage in adipose tissues [1], [3], [4], [9], [10].
Importantly with regards to anabolic growth cycles, GH secretion is tightly regulated by circadian rhythms, so an improper rhythm will inhibit optimal GH secretion regardless of optimal nutrition and training [11]–[13]. Thus, there is a special interest in “resetting the clock” in the strength training industry.
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| Formula | C23H31ClN4O3S |
| Molar mass | 479.04 g·mol−1 |
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**The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. Additionally, it is important to note that research chemicals are intended solely for laboratory study by professional researchers and are not intended for human consumption.**
