IGF-1 LR3

Mechanism of Action

IGF-1 works by binding and activating its own receptor, IGF-1R, which is present on the surface of many cell types in many tissues. This binding initiates intracellular signaling, which can regulate cellular DNA synthesis and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung cells. IGF-1 does not bind very well to IGF-1 binding proteins (IGFBPs), which results in more of the peptide being available for binding to important receptors.

Benefits

IGF-1 has been shown to stimulate muscle growth and increase strength, promote healing and prevent muscle wasting, enhance bone health and formation, and potentially improve insulin sensitivity and blood lipids in type 2 diabetic patients. It has also been shown to reduce neuronal death and protect neurons against insults like stroke, Alzheimer's disease, and Parkinson's disease.

Side Effects

Possible side effects of IGF-1 include joint problems, liver problems, overgrowth of some body tissues, heart damage, dangerous changes in blood sugar levels, impaired glucose metabolism and hypoglycemia, retinal edema, fatigue, changes in sexual function, and severe muscle pain. There is also a potential risk of cancer development when levels of IGF-1 rise too high.

Dangerous Interactions

IGF-1 may interact with other hormones and potentially modulate their effects on cancer. For example, it has been suggested that IGF-2 may antagonize the protective effect of IGF-1 by displacing it from IGFBPs. Additionally, anyone with prediabetes or diabetes should avoid these products due to how they impact blood glucose, which can lead to serious problems like fainting.

Dosing Guidelines

The dosage range for IGF-1 LR3 is upwards of 50 – 150mcg per day. Due to its much longer half-life than the DES variant, higher dosages can be utilized without as much of the risk for long-term effects on the body, though caution should still be utilized. It can be administered intramuscularly or subcutaneously, and use should not exceed cycle lengths of 30 days total before taking a minimum of 2 weeks break.

**The information provided on this post is intended solely for educational purposes and should not be considered a replacement for professional medical advice. Additionally, it is important to note that research chemicals are intended solely for laboratory study by professional researchers and are not intended for human consumption.