Enclomiphene

Mechanism of Action & Benefits:

Mechanism of Action of Enclomiphene

Enclomiphene is a selective estrogen receptor antagonist that works by antagonizing estrogen receptors in the pituitary gland. This action disrupts the negative feedback loop by estrogen towards the hypothalamic-pituitary-gonadal axis, ultimately resulting in an increase in gonadotropin secretion. By increasing gonadotropin secretion, enclomiphene stimulates the endogenous production of testosterone, particularly in men with secondary hypogonadism where the low levels of testosterone are due to inadequacies in the hypothalamic-pituitary axis.

Benefits

Enclomiphene is beneficial for Post Cycle Therapy (PCT) and as a testosterone base due to its ability to stimulate the body's natural production of testosterone. It is a Selective Estrogen Receptor Modulator (SERM) that blocks the conversion of testosterone to estrogen, thereby increasing testosterone levels.

Enclomiphene is used to treat men with low testosterone levels, a condition known as hypogonadism. The benefits of Enclomiphene therapy with PCT can be categorized into sexual health, physical health, and mental health. It plays a significant role in sperm production, which is essential for sexual functions. It also helps in preventing lean muscle mass reduction or atrophy, decreasing bone mineral density, and decreasing sexual drive, which are common effects of low testosterone levels.

Enclomiphene is a stereoisomer of Clomid, a popular SERM, and is considered to be just as effective with fewer drawbacks. It is prescribed by doctors as an alternative to hormone replacement therapy due to its effectiveness.

Clinical studies have shown that enclomiphene citrate increases men's Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), testosterone, and sperm counts.

As a PCT, enclomiphene works by selectively blocking estrogen receptors in the hypothalamus, which tricks the brain into thinking that there is a lack of estrogen, causing it to stimulate natural testosterone production.

This makes it an excellent option for those seeking to restore natural testosterone production after a steroid cycle.

Side effects:

  1. Increased Libido: While this may be seen as a benefit by some, an excessively increased libido can be disruptive.

  2. Mood Swings: Some users may experience mood swings or increased irritability.

  3. Acne: Hormonal changes induced by enclomiphene can lead to acne in some individuals.

  4. Vision Changes: As with other selective estrogen receptor modulators (SERMs), there is a potential for vision changes, although this side effect is more commonly associated with clomiphene citrate (Clomid), a related compound.

  5. Gastrointestinal Issues: Some users may experience gastrointestinal discomfort, such as nausea or abdominal pain.

  6. Headaches: Headaches are a possible side effect of enclomiphene use.

  7. Potential Increase in Testosterone: If testosterone levels become too high, it can lead to symptoms such as aggression or temper issues.

Interactions:

Enclomiphene, a selective estrogen receptor modulator (SERM), has been reported to interact with various drugs. The metabolism of enclomiphene can be decreased when combined with certain medications, which may affect its effectiveness or increase the risk of side effects. Some of the drugs that can decrease the metabolism of enclomiphene include:

  • Codeine

  • Curcumin

  • Cyclosporine

  • Dacomitinib

  • Abiraterone

  • Acebutolol

  • Acetaminophen

  • Adagrasib

  • Almotriptan

  • Alogliptin

  • Aminophenazone

  • Amiodarone

Additionally, enclomiphene's metabolism can be increased when combined with drugs such as abatacept and adalimumab. It's also important to note that enclomiphene has moderate interactions with at least 71 different drugs and mild interactions with at least 101 different drugs.

While enclomiphene has no listed serious interactions with other drugs, it is essential to be aware of any interactions that may result from taking it, especially in combination with other medications. It is always recommended to consult with a healthcare provider before starting, stopping, or changing the dosage of any medicine, including enclomiphene.

Furthermore, enclomiphene may interact with certain diseases, including hepatic dysfunction, abnormal uterine bleeding, liver disease or a history of liver disease, uncontrolled thyroid, or adrenal dysfunction.

Dosing Guidelines:

Enclomiphene citrate is used in bodybuilding to increase the body's natural testosterone production, which is beneficial during PCT or to use as a "Test Base" for mild suppressive compounds. The dosing guidelines for enclomiphene citrate in bodybuilding can vary, but common dosages range from 6mg/EOD to 25 mg/day.

**The information provided on this post is intended solely for educational purposes and should not be considered a replacement for professional medical advice. Additionally, it is important to note that research chemicals are intended solely for laboratory study by professional researchers and are not intended for human consumption.

Back to blog

Leave a comment